Professor Chris Bass
Professor of Applied Entomology
C.Bass@exeter.ac.uk
01326 259084
SERSF 1:22
Science and Engineering Research Support Facility (SERSF):, University of Exeter, Penryn Campus, Penryn, Cornwall, TR10 9FE, UK
Overview
Our group’s research exploits recent advances in transcriptomics, genomics and post-genomic functional approaches to understand adaptive evolution in insects. A significant focus of our work is understanding how insects detoxify the natural and synthetic xenobiotics they encounter in the environment. This includes both plant secondary metabolites and man-made insecticides.
Qualifications
2004 PhD Insect Molecular Biology (University of Nottingham/Rothamsted Research)
2000 Biology (University of Nottingham)
Career
2016 – present Chair in Applied Entomology – University of Exeter
2015 – present ERC Consolidator Fellow
2014 – 2015 Principal Research Scientist– Rothamsted Research
2009 – 2014 BBSRC Institute Career Path Fellow
2004 – 2009 Postdoctoral Research Fellow – Rothamsted Research
Research
Research interests
Our group's research aims to understand the molecular basis of adaptive traits in insects, with our primary interest the evolution of insect resistance to natural and synthetic insecticides. Whenever possible we translate this knowledge into tools and strategies to prevent, slow or overcome the development of resistance in pest insects. In addition to our work on crop pests we also aim to understand the intrinsic resistance of beneficial insects to insecticides, specifically bee pollinators. Finally we collaborate with colleagues in the UK and internationally to bring our expertise to the study of other evolutionary traits in insects.
Research themes
A. The evolution of metabolic resistance to synthetic and natural xenobiotics in crop pests
Our research in this theme aims to understand, at a molecular level, how a number of economically important crop pests evolve resistance to synthetic insecticides and the toxic secondary metabolites produced by the plants they feed on. This often involves the study of large superfamilies of metabolic enzymes, such as cytochrome P450s, that insects frequently use to detoxify xenobiotics. We work on a number of different insect species with the aphid, Myzus persicae, the brown planthopper, Nilaparvata lugens and the tomato leafminer, Tuta absoluta long-term models in our research.
Some of the questions our research on this topic aims to address are:
What enzymes are over-expressed in xenobiotic resistant strains in the field – how do they confer resistance?
What are the drivers of quantitative changes in detox gene expression in resistant insects (initial genomic changes)?
What is the relationship between host-adaptation and insecticide resistance – are their differences in polyphagous and monophagous insect species?
What is the role of qualitative changes in detoxification enzymes in resistance?
What can knowledge of the above teach us about evolution, gene regulation and protein structure/function?
B. The molecular basis of insecticide detoxification in bee pollinators
In this research theme we aim to understand the molecular basis of the intrinsic tolerance of bee pollinators to certain insecticides and the genes/proteins that determine sensitivity. An understanding of why certain insecticides are highly toxic to pest insects but not bees can be harnessed in the development of bee-safe insecticides (see current funding for ongoing projects on this topic).
C. Development of tools and approaches to study and combat resistance
Whenever possible we translate our fundamental research findings into tools and strategies to prevent, slow or overcome resistance. These include the development of DNA-based diagnostics to monitor the frequency and distribution of resistance, the development of inhibitors of the detoxification genes overexpressed in resistant insects and in vivo and in vitro screening tools which can be used to identify resistance breaking chemistry. In our research on this theme we have recently exploited the transgenic overexpression of crop pest (and bee) detoxification genes and gene editing (using CRISPR/Cas9) in Drosophila melanogaster.
D. Collaborations on other adaptive traits in insects
We collaborate with several other individuals/groups to bring our expertise to the study of other traits in insects. This includes both crop pests and disease vectors. Current example collaborations include:
Dr Chris Jones (BBSRC Future Leader Fellow)/ Dr Jason Chapman (Rothamsted Research) – the genetic basis of migration in the cotton bollworm, Helicoverpa armigera.
Deepa Paliwal (PhD student)/Dr Rob Jackson (University of Reading) – exploiting aphid killing bacteria
Research funding
Sustainable control of highly invasive pests (FP7-PEOPLE-2012-IRSES, Feb 13-17)
A genomic approach to understanding insecticide resistance in diamondback moth (Plutella xylostella) (BBSRC/Syngenta – Industrial CASE award, Oct 12-16) Supervisor with: Lin Field, Martin Williamson (Rothamsted) and Mark Paine (LSTM)
Aphid killing bacteria: how do they work and how can we exploit them? (University of Reading/Bayer, Oct 12-16) Supervisor with: Rob Jackson (PI - University of Reading), Lin Field and Tim Mauchline (Rothamsted)
Investigating the breakdown of chemical control in brown planthoppers from Asia (Bayer, Oct 13-17) Supervisor with: Emyr Davies (PI), Martin Williamson, Lin Field (Rothamsted) and Hilary Ranson (LSTM)
Bee toxicogenomics (Bayer, Jun 14-17) with Ralf Nauen (Bayer), Emyr Davies, Martin Williamson, Lin Field (Rothamsted)
The biological and molecular factors influencing the control of two whitefly species (Bemisia tabaci and Trialeurodes vaporium) on different host plants (BBSRC /Syngenta - Industrial CASE award, Oct 14-18) Supervisor with: Emyr Davies, Martin Williamson, Lin Field (Rothamsted) and Richard ffrench-Constant (Exeter)
Understanding the molecular and biochemical basis of insecticide selectivity against solitary bee pollinators (BBSRC/Bayer – Industrial CASE award, Oct 14-18) Supervisor with: Emyr Davies, Martin Williamson, Lin Field (Rothamsted) and Craig Wilding (Liverpool John Moores University)
Understanding and Exploiting the P450 Resistome –P450RESIST (ERC Consolidator Fellowship, Jan 16-21)
Publications
Journal articles
Dupeyron M, Singh K, Bass C, Hayward A (In Press). Evolution of Mutator transposable elements across eukaryotic diversity. Mobile DNA
Yang X, Shun D, Wei X, Yang J, Zhao Q, Yin C, Du T, Guo Z, Xia J, Yang Z, et al (In Press). MAPK-directed activation of the whitefly transcription factor CREB leads to P450-mediated imidacloprid resistance. Proceedings of the National Academy of Sciences of USA
Hayward A, Hunt BJ, Haas J, Bushnell-Crowther E, Troczka BJ, Pym A, Beadle K, Field J, Nelson DR, Nauen R, et al (2024). A cytochrome P450 insecticide detoxification mechanism is not conserved across the Megachilidae family of bees. Evolutionary Applications, 17(1). Abstract.
Oplopoiou M, Elias J, Slater R, Bass C, Zimmer CT (2024). Characterization of emamectin benzoate resistance in the diamondback moth, Plutella xylostella (Lepidoptera: Plutellidae). Pest Manag Sci, 80(2), 498-507. Abstract. Author URL.
Yin C, O'Reilly AO, Liu SN, Du TH, Gong PP, Zhang CJ, Wei XG, Yang J, Huang MJ, Fu BL, et al (2024). Dual mutations in the whitefly nicotinic Acetylcholine receptor β1 subunit confer Target-site resistance to multiple Neonicotinoid insecticides. PLoS Genetics, 20(2). Abstract.
Bass C, Hayward A, Troczka BJ, Haas J, Nauen R (2024). The molecular determinants of pesticide sensitivity in bee pollinators. The Science of the Total Environment, 915
Pym A, Troczka BJ, Hayward A, Zeng B, Gao CF, Elias J, Slater R, Zimmer CT, Bass C (2024). The role of the Bemisia tabaci and Trialeurodes vaporariorum cytochrome-P450 clade CYP6DPx in resistance to nicotine and neonicotinoids. Pesticide Biochemistry and Physiology, 198 Abstract.
King R, Boaventura D, Hunt BJ, Hayward A, Singh KS, Gutbrod O, Zimmer CT, Williamson MS, Field LM, Bass C, et al (2023). A chromosome-scale genome assembly of the pollen beetle,<i> Brassicogethes</i><i> aeneus,</i> provides insight into cytochrome P450-mediated pyrethroid resistance. ENTOMOLOGIA GENERALIS, 43(3), 639-648. Author URL.
Haas J, Beck E, Troczka BJ, Hayward A, Hertlein G, Zaworra M, Lueke B, Buer B, Maiwald F, Beck ME, et al (2023). A conserved hymenopteran-specific family of cytochrome P450s protects bee pollinators from toxic nectar alkaloids. Sci Adv, 9(15). Abstract. Author URL.
Pym A, Mina JGM, Troczka BJ, Hayward A, Daum E, Elias J, Slater R, Vontas J, Bass C, Zimmer CT, et al (2023). A single point mutation in the Bemisia tabaci cytochrome-P450 CYP6CM1 causes enhanced resistance to neonicotinoids. Insect Biochem Mol Biol, 156 Abstract. Author URL.
Trissi N, Troczka BJ, Ozsanlav-Harris L, Singh KS, Mallott M, Aishwarya V, O'Reilly A, Bass C, Wilding CS (2023). Differential regulation of the Tor gene homolog drives the red/green pigmentation phenotype in the aphid Myzuspersicae. Insect Biochem Mol Biol, 153 Abstract. Author URL.
Yang Q, Umina PA, Wei S, Bass C, Yu W, Robinson KL, Gill A, Zhan D, Ward SE, van Rooyen A, et al (2023). Diversity and Regional Variation of Endosymbionts in the Green Peach Aphid, <i>Myzus persicae</i> (Sulzer). DIVERSITY-BASEL, 15(2). Author URL.
Zeng B, Chen F-R, Sun H, Liu Y, Wu S-F, Bass C, Gao C-F (2023). Molecular and functional analysis of chitin synthase genes in Chilo suppressalis (Lepidoptera: Crambidae). Insect Sci, 30(3), 661-676. Abstract. Author URL.
Mueller V, Buer B, Lueke B, Mazzoni E, Pym A, Bass C, Nauen R (2023). Molecular characterization of pyrethroid resistance in field- collected populations of the pea aphid,<i> Acyrthosiphon</i><i> pisum</i>. ENTOMOLOGIA GENERALIS, 43(3), 627-637. Author URL.
Grant C, Singh KS, Hayward A, Hunt BJ, Troczka BJ, Pym A, Ahn S-J, Zeng B, Gao C-F, Leroux A, et al (2023). Overexpression of the UDP-glycosyltransferase UGT34A23 confers resistance to the diamide insecticide chlorantraniliprole in the tomato leafminer, Tuta absoluta. Insect Biochem Mol Biol, 159 Abstract. Author URL.
Zeng B, Zhang F, Liu YT, Wu SF, Bass C, Gao CF (2023). Symbiotic bacteria confer insecticide resistance by metabolizing buprofezin in the brown planthopper, Nilaparvata lugens (Stål). PLoS Pathogens, 19(12). Abstract.
Singh KS, Cordeiro EMG, Hunt BJ, Pandit AA, Soares PL, Correa AS, Zimmer CT, Zucchi MI, Batista C, Dow JAT, et al (2023). The genome sequence of the Neotropical brown stink bug, Euschistus heros provides insights into population structure, demographic history and signatures of adaptation. Insect Biochem Mol Biol, 152 Abstract. Author URL.
Bass C, Nauen R (2023). The molecular mechanisms of insecticide resistance in aphid crop pests. Insect Biochemistry and Molecular Biology, 156 Abstract.
Zeng B, Liu Y-T, Feng Z-R, Chen F-R, Wu S-F, Bass C, Gao C-F (2023). The overexpression of cytochrome P450 genes confers buprofezin resistance in the brown planthopper, Nilaparvata lugens (Stål). Pest Manag Sci, 79(1), 125-133. Abstract. Author URL.
Lira EC, Nascimento AR, Bass C, Omoto C, Cônsoli FL (2023). Transcriptomic investigation of the molecular mechanisms underlying resistance to the neonicotinoid thiamethoxam and the pyrethroid lambda-cyhalothrin in Euschistus heros (Hemiptera: Pentatomidae). Pest Manag Sci, 79(12), 5349-5361. Abstract. Author URL.
Baril T, Pym A, Bass C, Hayward A (2023). Transposon accumulation at xenobiotic gene family loci in aphids. Genome Res, 33(10), 1718-1733. Abstract. Author URL.
Velasquez-Vasconez PA, Hunt BJ, Dias RO, Souza TP, Bass C, Silva-Filho MC (2022). Adaptation of Helicoverpa armigera to Soybean Peptidase Inhibitors is Associated with the Transgenerational Upregulation of Serine Peptidases. International Journal of Molecular Sciences, 23(22), 14301-14301. Abstract.
Papadimitriou F, Folia M, Ilias A, Papapetrou P, Roditakis E, Bass C, Vontas J, T Margaritopoulos J (2022). Flupyradifurone resistance in Myzus persicae populations from peach and tobacco in Greece. Pest Manag Sci, 78(1), 304-312. Abstract. Author URL.
Doyle T, Jimenez-Guri E, Hawkes WLS, Massy R, Mantica F, Permanyer J, Cozzuto L, Hermoso Pulido T, Baril T, Hayward A, et al (2022). Genome-wide transcriptomic changes reveal the genetic pathways involved in insect migration. Mol Ecol, 31(16), 4332-4350. Abstract. Author URL.
Paliwal D, Hamilton AJ, Barrett GA, Alberti F, van Emden H, Monteil CL, Mauchline TH, Nauen R, Wagstaff C, Bass C, et al (2022). Identification of novel aphid-killing bacteria to protect plants. Microb Biotechnol, 15(4), 1203-1220. Abstract. Author URL.
Mavridis K, Papapostolou KM, Riga M, Ilias A, Michaelidou K, Bass C, Van Leeuwen T, Tsagkarakou A, Vontas J (2022). Multiple TaqMan qPCR and droplet digital PCR (ddPCR) diagnostics for pesticide resistance monitoring and management, in the major agricultural pest Tetranychus urticae. Pest Manag Sci, 78(1), 263-273. Abstract. Author URL.
Mavridis K, Papapostolou KM, Ilias A, Michaelidou K, Stavrakaki M, Roditakis E, Tsagkarakou A, Bass C, Vontas J (2022). Next-generation molecular diagnostics (TaqMan qPCR and ddPCR) for monitoring insecticide resistance in <i>Bemisia tabaci</i>. PEST MANAGEMENT SCIENCE, 78(11), 4994-5001. Author URL.
Pym A, Umina PA, Reidy-Crofts J, Troczka BJ, Matthews A, Gardner J, Hunt BJ, van Rooyen AR, Edwards OR, Bass C, et al (2022). Overexpression of UDP-glucuronosyltransferase and cytochrome P450 enzymes confers resistance to sulfoxaflor in field populations of the aphid, Myzus persicae. Insect Biochem Mol Biol, 143 Abstract. Author URL.
Duarte A, Pym A, Garrood WT, Troczka BJ, Zimmer CT, Davies TGE, Nauen R, O’Reilly AO, Bass C (2022). P450 gene duplication and divergence led to the evolution of dual novel functions and insecticide cross-resistance in the brown planthopper Nilaparvata lugens. PLOS Genetics, 18(6), e1010279-e1010279. Abstract.
Haas J, Hayward A, Buer B, Maiwald F, Nebelsiek B, Glaubitz J, Bass C, Nauen R (2022). Phylogenomic and functional characterization of an evolutionary conserved cytochrome P450-based insecticide detoxification mechanism in bees. Proc Natl Acad Sci U S A, 119(26). Abstract. Author URL.
Umina PA, Bass C, van Rooyen A, Chirgwin E, Arthur AL, Pym A, Mackisack J, Mathews A, Kirkland L (2022). Spirotetramat resistance in Myzus persicae (Sulzer) (Hemiptera: Aphididae) and its association with the presence of the A2666V mutation. Pest Manag Sci, 78(11), 4822-4831. Abstract. Author URL.
Nauen R, Bass C, Feyereisen R, Vontas J (2022). The Role of Cytochrome P450s in Insect Toxicology and Resistance. Annu Rev Entomol, 67, 105-124. Abstract. Author URL.
Haas J, Zaworra M, Glaubitz J, Hertlein G, Kohler M, Lagojda A, Lueke B, Maus C, Almanza M-T, Davies TGE, et al (2021). A toxicogenomics approach reveals characteristics supporting the honey bee (Apis mellifera L.) safety profile of the butenolide insecticide flupyradifurone. Ecotoxicol Environ Saf, 217 Abstract. Author URL.
Hu B, Huang H, Hu S, Ren M, Wei Q, Tian X, Esmail Abdalla Elzaki M, Bass C, Su J, Reddy Palli S, et al (2021). Changes in both trans- and cis-regulatory elements mediate insecticide resistance in a lepidopteron pest, Spodoptera exigua. PLoS Genet, 17(3). Abstract. Author URL.
Erdos Z, Chandler D, Bass C, Raymond B (2021). Controlling insecticide resistant clones of the aphid, Myzus persicae, using the entomopathogenic fungus Akanthomyces muscarius: fitness cost of resistance under pathogen challenge. Pest Manag Sci, 77(11), 5286-5293. Abstract. Author URL.
Yang X, Wei X, Yang J, Du T, Yin C, Fu B, Huang M, Liang J, Gong P, Liu S, et al (2021). Epitranscriptomic regulation of insecticide resistance. Sci Adv, 7(19). Abstract. Author URL.
Singh KS, De-Kayne R, Omufwoko KS, Martins DJ, Bass C, ffrench-Constant R, Martin SH (2021). Genome assembly of Danaus chrysippus and comparison with the Monarch Danaus plexippus. G3: Genes, Genomes, Genetics, 12(3).
Singh KS, Cordeiro EMG, Troczka BJ, Pym A, Mackisack J, Mathers TC, Duarte A, Legeai F, Robin S, Bielza P, et al (2021). Global patterns in genomic diversity underpinning the evolution of insecticide resistance in the aphid crop pest Myzus persicae. Commun Biol, 4(1). Abstract. Author URL.
Troczka BJ, Singh KS, Zimmer CT, Vontas J, Nauen R, Hayward A, Bass C (2021). Molecular innovations underlying resistance to nicotine and neonicotinoids in the aphid Myzus persicae. Pest Manag Sci, 77(12), 5311-5320. Abstract. Author URL.
Grant C, Jacobson R, Bass C (2021). Parthenogenesis in UK field populations of the tomato leaf miner, Tuta absoluta, exposed to the mating disruptor Isonet T. Pest Manag Sci, 77(7), 3445-3449. Abstract. Author URL.
Panini M, Chiesa O, Troczka BJ, Mallott M, Manicardi GC, Cassanelli S, Cominelli F, Hayward A, Mazzoni E, Bass C, et al (2021). Transposon-mediated insertional mutagenesis unmasks recessive insecticide resistance in the aphid Myzus persicae. Proc Natl Acad Sci U S A, 118(23). Abstract. Author URL.
Reid RJ, Troczka BJ, Kor L, Randall E, Williamson MS, Field LM, Nauen R, Bass C, Davies TGE (2020). Assessing the acute toxicity of insecticides to the buff-tailed bumblebee (Bombus terrestris audax). Pesticide Biochemistry and Physiology, 166 Abstract.
Singh KS, Hosken DJ, Wedell N, Ffrench-Constant R, Bass C, Baxter S, Paszkiewicz K, Sharma MD (2020). De Novo Genome Assembly of the Meadow Brown Butterfly, Maniola jurtina. G3 (Bethesda), 10(5), 1477-1484. Abstract. Author URL.
McLeman A, Troczka BJ, Homem RA, Duarte A, Zimmer C, Garrood WT, Pym A, Beadle K, Reid RJ, Douris V, et al (2020). Fly-Tox: a panel of transgenic flies expressing pest and pollinator cytochrome P450s. Pesticide Biochemistry and Physiology, 169 Abstract.
Lueke B, Douris V, Hopkinson JE, Maiwald F, Hertlein G, Papapostolou KM, Bielza P, Tsagkarakou A, Van Leeuwen T, Bass C, et al (2020). Identification and functional characterization of a novel acetyl-CoA carboxylase mutation associated with ketoenol resistance in Bemisia tabaci. Pesticide Biochemistry and Physiology, 166 Abstract.
Dupeyron M, Baril T, Bass C, Hayward A (2020). Phylogenetic analysis of the Tc1/mariner superfamily reveals the unexplored diversity of pogo-like elements. Mob DNA, 11 Abstract. Author URL.
Singh KS, Troczka BJ, Duarte A, Balabanidou V, Trissi N, Carabajal Paladino LZ, Nguyen P, Zimmer CT, Papapostolou KM, Randall E, et al (2020). The genetic architecture of a host shift: an adaptive walk protected an aphid and its endosymbiont from plant chemical defenses. Science Advances, 6(19). Abstract.
Douris V, Denecke S, Van Leeuwen T, Bass C, Nauen R, Vontas J (2020). Using CRISPR/Cas9 genome modification to understand the genetic basis of insecticide resistance: Drosophila and beyond. Pesticide Biochemistry and Physiology, 167 Abstract.
ffrench-Constant R, Martin S, Bass C, Singh K, Traut W, Gordon I, Smith D, Martins D (2020). Whole-chromosome hitchhiking driven by a male-killing endosymbiont. PLoS Biology
Hu B, Ren M, Fan J, Huang S, Wang X, Elzaki MEA, Bass C, Palli SR, Su J (2020). Xenobiotic transcription factors CncC and maf regulate expression of <i>CYP321A16</i> and <i>CYP332A1</i> that mediate chlorpyrifos resistance in <i>Spodoptera exigua</i>. JOURNAL OF HAZARDOUS MATERIALS, 398 Author URL.
Singh KS, Hosken DJ, Wedell N, ffrench-Constant R, Bass C, Baxter S, Paszkiewicz K, Sharma MD (2019). <i>De novo</i> genome assembly of the meadow brown butterfly, <i>Maniola jurtina</i>. Abstract.
Mallott M, Hamm S, Troczka BJ, Randall E, Pym A, Grant C, Baxter S, Vogel H, Shelton AM, Field LM, et al (2019). A flavin-dependent monooxgenase confers resistance to chlorantraniliprole in the diamondback moth, Plutella xylostella. Insect Biochem Mol Biol, 115 Abstract. Author URL.
Abeku TA, Helinski MEH, Kirby MJ, Kefyalew T, Awano T, Batisso E, Tesfaye G, Ssekitooleko J, Nicholas S, Erdmanis L, et al (2019). Correction to: Monitoring changes in malaria epidemiology and effectiveness of interventions in Ethiopia and Uganda: Beyond Garki Project baseline survey. Malar J, 18(1). Abstract. Author URL.
Singh KS, Troczka BJ, Beadle K, Field LM, Davies TGE, Williamson MS, Nauen R, Bass C (2019). Extension of Partial Gene Transcripts by Iterative Mapping of RNA-Seq Raw Reads. IEEE/ACM Transactions on Computational Biology and Bioinformatics, 16(3), 1036-1041. Abstract.
Beadle K, Singh KS, Troczka BJ, Randall E, Zaworra M, Zimmer CT, Hayward A, Reid R, Kor L, Kohler M, et al (2019). Genomic insights into neonicotinoid sensitivity in the solitary bee Osmia bicornis. PLoS Genet, 15(2). Abstract. Author URL.
Pym A, Singh KS, Nordgren Ã…, Davies TGE, Zimmer CT, Elias J, Slater R, Bass C (2019). Host plant adaptation in the polyphagous whitefly, Trialeurodes vaporariorum, is associated with transcriptional plasticity and altered sensitivity to insecticides. BMC Genomics, 20(1). Abstract. Author URL.
Troczka BJ, Homem RA, Reid R, Beadle K, Kohler M, Zaworra M, Field LM, Williamson MS, Nauen R, Bass C, et al (2019). Identification and functional characterisation of a novel N-cyanoamidine neonicotinoid metabolising cytochrome P450, CYP9Q6, from the buff-tailed bumblebee Bombus terrestris. Insect Biochem Mol Biol, 111 Abstract. Author URL.
Carabajal Paladino LZ, ProvaznÃková I, Berger M, Bass C, Aratchige NS, López SN, Marec F, Nguyen P (2019). Sex Chromosome Turnover in Moths of the Diverse Superfamily Gelechioidea. Genome Biol Evol, 11(4), 1307-1319. Abstract. Author URL.
Grant C, Jacobson R, Ilias A, Berger M, Vasakis E, Bielza P, Zimmer CT, Williamson MS, Ffrench-Constant RH, Vontas J, et al (2019). The evolution of multiple-insecticide resistance in UK populations of tomato leafminer, Tuta absoluta. Pest Manag Sci, 75(8), 2079-2085. Abstract. Author URL.
Hawkins NJ, Bass C, Dixon A, Neve P (2019). The evolutionary origins of pesticide resistance. Biol Rev Camb Philos Soc, 94(1), 135-155. Abstract. Author URL.
Hayward A, Beadle K, Singh KS, Exeler N, Zaworra M, Almanza M-T, Nikolakis A, Garside C, Glaubitz J, Bass C, et al (2019). The leafcutter bee, Megachile rotundata, is more sensitive to N-cyanoamidine neonicotinoid and butenolide insecticides than other managed bees. Nature Ecology & Evolution, 3(11), 1521-1524.
Dermauw W, Pym A, Bass C, Van Leeuwen T, Feyereisen R (2018). Does host plant adaptation lead to pesticide resistance in generalist herbivores?. Current Opinion in Insect Science, 26, 25-33. Abstract.
Bass C, Jones CM (2018). Editorial overview: Pests and resistance: Resistance to pesticides in arthropod crop pests and disease vectors: mechanisms, models and tools. Current Opinion in Insect Science, 27, iv-vii.
Jones CM, Lim KS, Chapman JW, Bass C (2018). Genome-Wide Characterization of DNA Methylation in an Invasive Lepidopteran Pest, the Cotton Bollworm Helicoverpa armigera. G3 (Bethesda), 8(3), 779-787. Abstract. Author URL.
Zimmer C, Garrood W, Singh K, Randall E, Bettina L, Gutbrod O, Matthiesen S, Kohler M, Nauen R, Davies TGE, et al (2018). Neofunctionalization of Duplicated P450 Genes Drives the Evolution of Insecticide Resistance in the Brown Planthopper. Current Biology, 28, 268-274.
Bass C, Field LM (2018). Neonicotinoids. Current Biology, 28(14), R772-R773. Abstract.
Manjon C, Troczka B, Zaworra M, Beadle K, Randall E, Hertlein G, Singh K, Zimmer C, Homem R, Lueke B, et al (2018). Unravelling the molecular determinants of bee sensitivity to neonicotinoid insecticides. Current Biology, 28, 1-7.
Panini M, Tozzi F, Zimmer CT, Bass C, Field L, Borzatta V, Mazzoni E, Moores G (2017). Biochemical evaluation of interactions between synergistic molecules and phase I enzymes involved in insecticide resistance in B- and Q-type Bemisia tabaci (Hemiptera: Aleyrodidae). Pest Manag Sci, 73(9), 1873-1882. Abstract. Author URL.
ffrench-Constant RH, Bass C (2017). Does resistance really carry a fitness cost?. Current Opinion in Insect Science, 21, 39-46. Abstract.
Garrood WT, Zimmer CT, Gutbrod O, Lüke B, Williamson MS, Bass C, Nauen R, Emyr Davies TG (2017). Influence of the RDL A301S mutation in the brown planthopper Nilaparvata lugens on the activity of phenylpyrazole insecticides. Pesticide Biochemistry and Physiology, 142, 1-8. Abstract.
Abeku TA, Helinski MEH, Kirby MJ, Ssekitooleko J, Bass C, Kyomuhangi I, Okia M, Magumba G, Meek SR (2017). Insecticide resistance patterns in Uganda and the effect of indoor residual spraying with bendiocarb on kdr L1014S frequencies in Anopheles gambiae s.s. Malar J, 16(1). Abstract. Author URL.
Haddi K, Berger M, Bielza P, Rapisarda C, Williamson MS, Moores G, Bass C (2017). Mutation in the ace-1 gene of the tomato leaf miner (Tuta absoluta) associated with organophosphates resistance. Journal of Applied Entomology, 141(8), 612-619. Abstract.
Roditakis E, Steinbach D, Moritz G, Vasakis E, Stavrakaki M, Ilias A, GarcÃa-Vidal L, MartÃnez-Aguirre MDR, Bielza P, Morou E, et al (2017). Ryanodine receptor point mutations confer diamide insecticide resistance in tomato leafminer, Tuta absoluta (Lepidoptera: Gelechiidae). Insect Biochem Mol Biol, 80, 11-20. Abstract. Author URL.
Panini M, Tozzi F, Bass C, Zimmer CT, Field L, Borzatta V, Mazzoni E, Moores G (2017). The interactions of piperonyl butoxide and analogues with the metabolic enzymes FE4 and CYP6CY3 of the green peach aphid Myzus persicae (Hemiptera: Aphididae). Pest Manag Sci, 73(2), 371-379. Abstract. Author URL.
Zimmer CT, Panini M, Singh KS, Randall EL, Field LM, Roditakis E, Mazzoni E, Bass C (2017). Use of the synergist piperonyl butoxide can slow the development of alpha-cypermethrin resistance in the whitefly Bemisia tabaci. Insect Mol Biol, 26(2), 152-163. Abstract. Author URL.
Zimmer CT, Garrood WT, Puinean AM, Eckel-Zimmer M, Williamson MS, Davies TGE, Bass C (2016). A CRISPR/Cas9 mediated point mutation in the alpha 6 subunit of the nicotinic acetylcholine receptor confers resistance to spinosad in Drosophila melanogaster. Insect Biochem Mol Biol, 73, 62-69. Abstract. Author URL.
Garrood WT, Zimmer CT, Gorman KJ, Nauen R, Bass C, Davies TGE (2016). Field-evolved resistance to imidacloprid and ethiprole in populations of brown planthopper Nilaparvata lugens collected from across South and East Asia. Pest Management Science, 72(1), 140-149. Abstract.
Alptekin S, Bass C, Nicholls C, Paine MJI, Clark SJ, Field L, Moores GD (2016). Induced thiacloprid insensitivity in honeybees (Apis mellifera L.) is associated with up-regulation of detoxification genes. Insect Mol Biol, 25(2), 171-180. Abstract. Author URL.
Berger M, Puinean AM, Randall E, Zimmer CT, Silva WM, Bielza P, Field LM, Hughes D, Mellor I, Hassani-Pak K, et al (2016). Insecticide resistance mediated by an exon skipping event. Mol Ecol, 25(22), 5692-5704. Abstract. Author URL.
Ffrench-Constant RH, Williamson MS, Davies TGE, Bass C (2016). Ion channels as insecticide targets. J Neurogenet, 30(3-4), 163-177. Abstract. Author URL.
Bass C, Jones CM (2016). Mosquitoes boost body armor to resist insecticide attack. Proc Natl Acad Sci U S A, 113(33), 9145-9147. Author URL.
Silva WM, Berger M, Bass C, Williamson M, Moura DMN, Ribeiro LMS, Siqueira HAA (2016). Mutation (G275E) of the nicotinic acetylcholine receptor α6 subunit is associated with high levels of resistance to spinosyns in Tuta absoluta (Meyrick) (Lepidoptera: Gelechiidae). Pesticide Biochemistry and Physiology, 131, 1-8. Abstract.
Jones CM, Papanicolaou A, Mironidis GK, Vontas J, Yang Y, Lim KS, Oakeshott JG, Bass C, Chapman JW (2015). Genomewide transcriptional signatures of migratory flight activity in a globally invasive insect pest. MOLECULAR ECOLOGY, 24(19), 4901-4911. Author URL.
Troczka BJ, Williams AJ, Bass C, Williamson MS, Field LM, Davies TGE (2015). Molecular cloning, characterisation and mRNA expression of the ryanodine receptor from the peach-potato aphid, Myzus persicae. Gene, 556(2), 106-112. Abstract. Author URL.
Abeku TA, Helinski MEH, Kirby MJ, Kefyalew T, Awano T, Batisso E, Tesfaye G, Ssekitooleko J, Nicholas S, Erdmanis L, et al (2015). Monitoring changes in malaria epidemiology and effectiveness of interventions in Ethiopia and Uganda: Beyond Garki Project baseline survey. Malar J, 14 Abstract. Author URL.
Zhang Y, Wang X, Yang B, Hu Y, Huang L, Bass C, Liu Z (2015). Reduction in mRNA and protein expression of a nicotinic acetylcholine receptor α8 subunit is associated with resistance to imidacloprid in the brown planthopper, Nilaparvata lugens. J Neurochem, 135(4), 686-694. Abstract. Author URL.
Silva WM, Berger M, Bass C, Balbino VQ, Amaral MHP, Campos MR, Siqueira HAA (2015). Status of pyrethroid resistance and mechanisms in Brazilian populations of Tuta absoluta. Pestic Biochem Physiol, 122, 8-14. Abstract. Author URL.
Bass C, Denholm I, Williamson MS, Nauen R (2015). The global status of insect resistance to neonicotinoid insecticides. Pestic Biochem Physiol, 121, 78-87. Abstract. Author URL.
Zimmer CT, Maiwald F, Schorn C, Bass C, Ott M-C, Nauen R (2014). A de novo transcriptome of European pollen beetle populations and its analysis, with special reference to insecticide action and resistance. Insect Mol Biol, 23(4), 511-526. Abstract. Author URL.
Dabiré RK, Namountougou M, Diabaté A, Soma DD, Bado J, Toé HK, Bass C, Combary P (2014). Distribution and frequency of kdr mutations within Anopheles gambiae s.l. populations and first report of the ace.1 G119S mutation in Anopheles arabiensis from Burkina Faso (West Africa). PLoS One, 9(7). Abstract. Author URL.
Zimmer CT, Bass C, Williamson MS, Kaussmann M, Wölfel K, Gutbrod O, Nauen R (2014). Molecular and functional characterization of CYP6BQ23, a cytochrome P450 conferring resistance to pyrethroids in European populations of pollen beetle, Meligethes aeneus. Insect Biochem Mol Biol, 45, 18-29. Abstract. Author URL.
Bass C, Puinean AM, Zimmer CT, Denholm I, Field LM, Foster SP, Gutbrod O, Nauen R, Slater R, Williamson MS, et al (2014). The evolution of insecticide resistance in the peach potato aphid, Myzus persicae. Insect Biochemistry and Molecular Biology, 51(1), 41-51. Abstract.
Vezenegho SB, Chiphwanya J, Hunt RH, Coetzee M, Bass C, Koekemoer LL (2013). Characterization of the Anopheles funestus group, including Anopheles funestus-like, from Northern Malawi. Transactions of the Royal Society of Tropical Medicine and Hygiene, 107(12), 753-762. Abstract.
Puinean AM, Elias J, Slater R, Warren A, Field LM, Williamson MS, Bass C (2013). Development of a high-throughput real-time PCR assay for the detection of the R81T mutation in the nicotinic acetylcholine receptor of neonicotinoid-resistant Myzus persicae. Pest Manag Sci, 69(2), 195-199. Abstract. Author URL.
Namountougou M, Diabaté A, Etang J, Bass C, Sawadogo SP, Gnankinié O, Baldet T, Martin T, Chandre F, Simard F, et al (2013). First report of the L1014S kdr mutation in wild populations of Anopheles gambiae M and S molecular forms in Burkina Faso (West Africa). Acta Tropica, 125(2), 123-127. Abstract.
Bass C, Zimmer CT, Riveron JM, Wilding CS, Wondji CS, Kaussmann M, Field LM, Williamson MS, Nauen R (2013). Gene amplification and microsatellite polymorphism underlie a recent insect host shift. Proceedings of the National Academy of Sciences of the United States of America, 110(48), 19460-19465. Abstract.
Carvalho RA, Omoto C, Field LM, Williamson MS, Bass C (2013). Investigating the molecular mechanisms of organophosphate and pyrethroid resistance in the fall armyworm Spodoptera frugiperda. PLoS One, 8(4). Abstract. Author URL.
Yang N, Xie W, Jones CM, Bass C, Jiao X, Yang X, Liu B, Li R, Zhang Y (2013). Transcriptome profiling of the whitefly Bemisia tabaci reveals stage-specific gene expression signatures for thiamethoxam resistance. Insect Molecular Biology, 22(5), 485-496. Abstract.
Carvalho R, Yang Y, Field LM, Gorman K, Moores G, Williamson MS, Bass C (2012). Chlorpyrifos resistance is associated with mutation and amplification of the acetylcholinesterase-1 gene in the tomato red spider mite, Tetranychus evansi. Pesticide Biochemistry and Physiology, 104(2), 143-149. Abstract.
Bass C, Hebsgaard MB, Hughes J (2012). Genomic resources for the brown planthopper, Nilaparvata lugens: Transcriptome pyrosequencing and microarray design. Insect Science, 19(1), 1-12. Abstract.
Haddi K, Berger M, Bielza P, Cifuentes D, Field LM, Gorman K, Rapisarda C, Williamson MS, Bass C (2012). Identification of mutations associated with pyrethroid resistance in the voltage-gated sodium channel of the tomato leaf miner (Tuta absoluta). Insect Biochemistry and Molecular Biology, 42(7), 506-513. Abstract.
Karatolos N, Williamson MS, Denholm I, Gorman K, ffrench-Constant RH, Bass C (2012). Over-expression of a cytochrome P450 is associated with resistance to pyriproxyfen in the greenhouse whitefly trialeurodes vaporariorum. PLoS ONE, 7(2). Abstract.
Dabiré RK, Namountougou M, Sawadogo SP, Yaro LB, Toé HK, Ouari A, Gouagna LC, Simard F, Chandre F, Baldet T, et al (2012). Population dynamics of Anopheles gambiae s.l. in Bobo-Dioulasso city: Bionomics, infection rate and susceptibility to insecticides. Parasites and Vectors, 5(1). Abstract.
Troczka B, Zimmer CT, Elias J, Schorn C, Bass C, Davies TGE, Field LM, Williamson MS, Slater R, Nauen R, et al (2012). Resistance to diamide insecticides in diamondback moth, Plutella xylostella (Lepidoptera: Plutellidae) is associated with a mutation in the membrane-spanning domain of the ryanodine receptor. Insect Biochem Mol Biol, 42(11), 873-880. Abstract. Author URL.
Nauen R, Zimmer CT, Andrews M, Slater R, Bass C, Ekbom B, Gustafsson G, Hansen LM, Kristensen M, Zebitz CPW, et al (2012). Target-site resistance to pyrethroids in European populations of pollen beetle, Meligethes aeneus F. Pesticide Biochemistry and Physiology, 103(3), 173-180. Abstract.
Hofinger BJ, Russell JR, Bass CG, Baldwin T, Dos Reis M, Hedley PE, Li Y, MacAulay M, Waugh R, Hammond-Kosack KE, et al (2011). An exceptionally high nucleotide and haplotype diversity and a signature of positive selection for the eIF4E resistance gene in barley are revealed by allele mining and phylogenetic analyses of natural populations. Molecular Ecology, 20(17), 3653-3668. Abstract.
Brown NA, Bass C, Baldwin TK, Chen H, Massot F, Carion PWC, Urban M, van de Meene AML, Hammond-Kosack KE (2011). Characterisation of the Fusarium graminearum-Wheat Floral Interaction. J Pathog, 2011 Abstract. Author URL.
Bass C, Field LM (2011). Gene amplification and insecticide resistance. Pest Manag Sci, 67(8), 886-890. Abstract. Author URL.
Bass C, Puinean AM, Andrews M, Cutler P, Daniels M, Elias J, Paul VL, Crossthwaite AJ, Denholm I, Field LM, et al (2011). Mutation of a nicotinic acetylcholine receptor β subunit is associated with resistance to neonicotinoid insecticides in the aphid Myzus persicae. BMC Neuroscience, 12 Abstract.
Bass C, Carvalho RA, Oliphant L, Puinean AM, Field LM, Nauen R, Williamson MS, Moores G, Gorman K (2011). Overexpression of a cytochrome P450 monooxygenase, CYP6ER1, is associated with resistance to imidacloprid in the brown planthopper, Nilaparvata lugens. Insect Molecular Biology, 20(6), 763-773. Abstract.
Araújo RA, Williamson MS, Bass C, Field LM, Duce IR (2011). Pyrethroid resistance in Sitophilus zeamais is associated with a mutation (T929I) in the voltage-gated sodium channel. Insect Molecular Biology, 20(4), 437-445. Abstract.
Araújo RA, Williamson MS, Bass C, Field LM, Duce IR (2011). Pyrethroid resistance in Sitophilus zeamais is associated with a mutation (T929I) in the voltage-gated sodium channel. Insect Molecular Biology Abstract.
Nyoni BN, Gorman K, Mzilahowa T, Williamson MS, Navajas M, Field LM, Bass C (2011). Pyrethroid resistance in the tomato red spider mite, Tetranychus evansi, is associated with mutation of the para-type sodium channel. Pest Management Science, 67(8), 891-897. Abstract.
Karatolos N, Pauchet Y, Wilkinson P, Chauhan R, Denholm I, Gorman K, Nelson DR, Bass C, ffrench-Constant RH, Williamson MS, et al (2011). Pyrosequencing the transcriptome of the greenhouse whitefly, Trialeurodes vaporariorum reveals multiple transcripts encoding insecticide targets and detoxifying enzymes. BMC Genomics, 12 Abstract.
Puinean AM, Foster SP, Oliphant L, Denholm I, Field LM, Millar NS, Williamson MS, Bass C (2010). Amplification of a cytochrome P450 gene is associated with resistance to neonicotinoid insecticides in the aphid Myzus persicae. PLoS Genetics, 6(6), 1-11. Abstract.
de Carvalho RA, Limia CEG, Bass C, de Azeredo-Espin AML (2010). Changes in the frequency of the G137D and W251S mutations in the carboxylesterase E3 gene of Cochliomyia hominivorax (Diptera: Calliphoridae) populations from Uruguay. Veterinary Parasitology, 170(3-4), 297-301. Abstract.
Bass C, Nikou D, Vontas J, Williamson MS, Field LM (2010). Development of high-throughput real-time PCR assays for the identification of insensitive acetylcholinesterase (ace-1<sup>R</sup>) in Anopheles gambiae. Pesticide Biochemistry and Physiology, 96(2), 80-85. Abstract.
Bass C, Nikou D, Vontas J, Donnelly MJ, Williamson MS, Field LM (2010). The Vector Population Monitoring Tool (VPMT): High-Throughput DNA-Based Diagnostics for the Monitoring of Mosquito Vector Populations. Malar Res Treat, 2010 Abstract. Author URL.
Vezenegho SB, Bass C, Puinean M, Williamson MS, Field LM, Coetzee M, Koekemoer LL (2009). Development of multiplex real-time PCR assays for identification of members of the Anopheles funestus species group. Malaria Journal, 8(1). Abstract.
Dabiré KR, Diabaté A, Namontougou M, Djogbenou L, Kengne P, Simard F, Bass C, Baldet T (2009). Distribution of insensitive acetylcholinesterase (ace-1<sup>R</sup>) in Anopheles gambiae s.l. populations from Burkina Faso (West Africa). Tropical Medicine and International Health, 14(4), 396-403. Abstract.
Dabiré KR, Diabaté A, Namountougou M, Toé KH, Ouari A, Kengne P, Bass C, Baldet T (2009). Distribution of pyrethroid and DDT resistance and the L1014F kdr mutation in Anopheles gambiae s.l. from Burkina Faso (West Africa). Transactions of the Royal Society of Tropical Medicine and Hygiene, 103(11), 1113-1120. Abstract.
Ramphul U, Boase T, Bass C, Okedi LM, Donnelly MJ, Müller P (2009). Insecticide resistance and its association with target-site mutations in natural populations of Anopheles gambiae from eastern Uganda. Transactions of the Royal Society of Tropical Medicine and Hygiene, 103(11), 1121-1126. Abstract.
Ridl FC, Bass C, Torrez M, Govender D, Ramdeen V, Yellot L, Edu AE, Schwabe C, Mohloai P, Maharaj R, et al (2008). A pre-intervention study of malaria vector abundance in Rio Muni, Equatorial Guinea: Their role in malaria transmission and the incidence of insecticide resistance alleles. Malaria Journal, 7 Abstract.
Bass C, Williamson MS, Field LM (2008). Development of a multiplex real-time PCR assay for identification of members of the Anopheles gambiae species complex. Acta Trop, 107(1), 50-53. Abstract. Author URL.
Bass C, Nikou D, Blagborough AM, Vontas J, Sinden RE, Williamson MS, Field LM (2008). PCR-based detection of Plasmodium in Anopheles mosquitoes: a comparison of a new high-throughput assay with existing methods. Malaria Journal, 7 Abstract.
Mzilahowa T, Ball AJ, Bass C, Morgan JC, Nyoni B, Steen K, Donnelly MJ, Wilding CS (2008). Reduced susceptibility to DDT in field populations of Anopheles quadriannulatus and Anopheles arabiensis in Malawi: Evidence for larval selection. Medical and Veterinary Entomology, 22(3), 258-263. Abstract.
Bass C, Nikou D, Donnelly MJ, Williamson MS, Ranson H, Ball A, Vontas J, Field LM (2007). Detection of knockdown resistance (kdr) mutations in Anopheles gambiae: a comparison of two new high-throughput assays with existing methods. Malaria Journal, 6 Abstract.
Bass C, Williamson MS, Wilding CS, Donnelly MJ, Field LM (2007). Identification of the main malaria vectors in the Anopheles gambiae species complex using a TaqMan real-time PCR assay. Malar J, 6 Abstract. Author URL.
Bass C, Lansdell SJ, Millar NS, Schroeder I, Turberg A, Field LM, Williamson MS (2006). Molecular characterisation of nicotinic acetylcholine receptor subunits from the cat flea, Ctenocephalides felis (Siphonaptera: Pulicidae). Insect Biochem Mol Biol, 36(1), 86-96. Abstract. Author URL.
Bass C, Hendley R, Adams MJ, Hammond-Kosack KE, Kanyuka K (2006). The Sbm1 locus conferring resistance to Soil-borne cereal mosaic virus maps to a gene-rich region on 5DL in wheat. Genome, 49(9), 1140-1148. Abstract. Author URL.
Hill N, Moor G, Cameron MM, Butlin A, Preston S, Williamson MS, Bass C (2005). Single blind, randomised, comparative study of the Bug Buster kit and over the counter pediculicide treatments against head lice in the United Kingdom. British Medical Journal, 331(7513), 384-386. Abstract.
Bass C, Schroeder I, Turberg A, M Field L, Williamson MS (2004). Identification of mutations associated with pyrethroid resistance in the para-type sodium channel of the cat flea, Ctenocephalides felis. Insect Biochem Mol Biol, 34(12), 1305-1313. Abstract. Author URL.
Bass C, Schroeder I, Turberg A, Field LM, Williamson MS (2004). Identification of the Rdl mutation in laboratory and field strains of the cat flea, Ctenocephalides felis (Siphonaptera: Pulicidae). Pest Manag Sci, 60(12), 1157-1162. Abstract. Author URL.
Chapters
Field LM, Bass C, Davies TGE, Williamson MS, Zhou JJ (2017). Aphid genomics and its contribution to understanding aphids as crop pests. In (Ed) Aphids as crop pests, CABI Publishing, 37-49.
External Engagement and Impact
Committee/panel activities
2003 – present Science Ambassador under the UKs Science, Technology, Engineering and Mathematics Network (STEMNET’s) flagship programme. This involves science communication both in schools and at Rothamsted.
2008 – present Elected Fellow of the Royal Entomological Society
Editorial responsibilities
2004 – present Reviewer for >30 international journals. Reviewer for several national funding bodies including EU –H2020, BBSRC, MRC (UK), DFG (Germany), ANR (France).
Supervision / Group
Postdoctoral researchers
- Ana Duarte
- Emma Randall (Research Assistant)
- Kumar Saurabh Singh
- Christoph Zimmer
Postgraduate researchers
- Katherine Beadle BBSRC/Bayer CASE award
- Charles Grant
- Sarah Hamm
- Angela Hayward
- Adam Pym
Research Technicians
- Victoria Mallott
Alumni
- Manuela Eckel-Zimmer (Research Assistant)
- Mark Mallott (based at Rothamsted Research) – BBSRC/Syngenta CASE award
