Ecology and Conservation

Dr David Walker-Sünderhauf

Dr David Walker-Sünderhauf

Postdoctoral Research Fellow

 D.Walker-Sunderhauf@exeter.ac.uk

 Environment and Sustainability Institute 

 

Environment and Sustainability Institute, University of Exeter, Penryn Campus, Penryn, Cornwall, TR10 9FE, UK

Overview

I am researching antibiotic resistance, and how we might remove antibiotic resistance genes using CRISPR as a biotechnology. Beyond that, I am interested in plasmid and mobile genetic element ecology and interactions with their bacterial hosts.

Previously, I undertook my PhD in this group supervised by Prof Stineke van Houte and Prof Will Gaze. I also completed an MRes degree on the interplay of Restriction-Modification and CRISPR-Cas under the supervision of Prof Edze Westra.

You can also find me on Twitter (@davvi36) and Researchgate, or my profile on the van Houte lab website.

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Research

Research projects

Removal of Antimicrobial Resistance Genes from bacterial strains and communities using CRISPR-Cas9

Research networks

Microbes and Society (University of Exeter)

AMR Alliance (GW4)

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Publications

Journal articles

Sünderhauf D, Klümper U, Gaze WH, Westra ER, van Houte S (2023). Interspecific competition can drive plasmid loss from a focal species in a microbial community. The ISME Journal, 17(10), 1765-1773. Abstract.
Walker-Sünderhauf D, Klümper U, Pursey E, Westra ER, Gaze WH, van Houte S (2023). Removal of AMR plasmids using a mobile, broad host-range CRISPR-Cas9 delivery tool. Microbiology (Reading), 169(5). Abstract.  Author URL.
Common J, Walker-Sünderhauf D, van Houte S, Westra ER (2020). Diversity in CRISPR-based immunity protects susceptible genotypes by restricting phage spread and evolution. J Evol Biol, 33(8), 1097-1108. Abstract.  Author URL.
Common J, Walker-Sünderhauf D, van Houte S, Westra ER (2019). Diversity in CRISPR-based immunity protects susceptible genotypes by restricting phage spread and evolution. Abstract.
Pursey E, Sünderhauf D, Gaze WH, Westra ER, van Houte S (2018). CRISPR-Cas antimicrobials: Challenges and future prospects. PLoS Pathog, 14(6).  Author URL.
Westra ER, Sünderhauf D, Landsberger M, Buckling A (2017). Mechanisms and consequences of diversity-generating immune strategies. Nat Rev Immunol, 17(11), 719-728. Abstract.  Author URL.

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